Collaborations

Over the years our lab has been fortunate to have an outstanding group of collaborators listed here in reverse chronological order with the publications.

Nat is the Krishnan-Shah Family Professor of Chemical and Systems Biology at Stanford

1. A Bivalent Molecular Glue Linking Lysine Acetyltransferases to Oncogene-induced Cell Death. Nix MN, Gourisankar S, Sarott RC, Dwyer BG, Nettles SA, Martinez MM, Abuzaid H, Yang H, Wang Y, Simanauskaite JM, Romero BA, Jones HM, Krokhotin A, Lowensohn TN, Chen L, Low C, Davis MM, Fernandez D, Zhang T, Green MR, Hinshaw SM, Gray NS, Crabtree GR.bioRxiv [Preprint]. 2025 Mar 17:2025.03.14.643404. doi: 10.1101/2025.03.14.643404.PMID: 40166243
2. Relocalizing transcriptional kinases to activate apoptosis. Sarott RC, Gourisankar S, Karim B, Nettles S, Yang H, Dwyer BG, Simanauskaite JM, Tse J, Abuzaid H, Krokhotin A, Zhang T, Hinshaw SM, Green MR, Crabtree GR, Gray NS. Science. 2024 Oct 4;386(6717):eadl5361. doi: 10.1126/science.adl5361. Epub 2024 Oct 4.PMID: 39361741
3. Rewiring cancer drivers to activate apoptosis. Gourisankar S, Krokhotin A, Ji W, Liu X, Chang CY, Kim SH, Li Z, Wenderski W, Simanauskaite JM, Yang H, Vogel H, Zhang T, Green MR, Gray NS, Crabtree GR. Nature. 2023 Aug;620(7973):417-425. doi: 10.1038/s41586-023-06348-2. Epub 2023 Jul 26.PMID: 37495688

Professor in the Genetics Department at Stanford University School of Medicine

1. PU.1 and BCL11B sequentially cooperate with RUNX1 to anchor mSWI/SNF to poise the T cell effector landscape. Gamble N, Bradu A, Caldwell JA, McKeever J, Bolonduro O, Ermis E, Kaiser C, Kim Y, Parks B, Klemm S, Greenleaf WJ, Crabtree GR, Koh AS.Nat Immunol. 2024 May;25(5):860-872. doi: 10.1038/s41590-024-01807-y. Epub 2024 Apr 17.PMID: 38632339 Free PMC article.
2. Increased ACTL6A occupancy within mSWI/SNF chromatin remodelers drives human squamous cell carcinoma.Chang CY, Shipony Z, Lin SG, Kuo A, Xiong X, Loh KM, Greenleaf WJ, Crabtree GR.Mol Cell. 2021 Dec 16;81(24):4964-4978.e8. doi: 10.1016/j.molcel.2021.10.005. Epub 2021 Oct 22.PMID: 34687603Free PMC article.
3. Rapid chromatin repression by Aire provides precise control of immune tolerance. Koh AS, Miller EL, Buenrostro JD, Moskowitz DM, Wang J, Greenleaf WJ, Chang HY, Crabtree GR.Nat Immunol. 2018 Feb;19(2):162-172. doi: 10.1038/s41590-017-0032-8. Epub 2018 Jan 15.PMID: 29335648Free PMC article.
4. TOP2 synergizes with BAF chromatin remodeling for both resolution and formation of facultative heterochromatin. Miller EL, Hargreaves DC, Kadoch C, Chang CY, Calarco JP, Hodges C, Buenrostro JD, Cui K, Greenleaf WJ, Zhao K, Crabtree GR.Nat Struct Mol Biol. 2017 Apr;24(4):344-352. doi: 10.1038/nsmb.3384. Epub 2017 Feb 27.PMID: 28250416

RZ Cao Professor of Medicine, Genetics and Biomedical Data Science

Christina Curtis, PhD, MSc is the RZ Cao Professor of Medicine, Genetics and Biomedical Data Science at Stanford University where she leads the Cancer Computational and Systems Biology group.

1. A CRISPR/Cas9-Engineered ARID1A-Deficient Human Gastric Cancer Organoid Model Reveals Essential and Nonessential Modes of Oncogenic Transformation.Lo YH, Kolahi KS, Du Y, Chang CY, Krokhotin A, Nair A, Sobba WD, Karlsson K, Jones SJ, Longacre TA, Mah AT, Tercan B, Sockell A, Xu H, Seoane JA, Chen J, Shmulevich I, Weissman JS, Curtis C, Califano A, Fu H, Crabtree GR, Kuo CJ.Cancer Discov. 2021 Jun;11(6):1562-1581. doi: 10.1158/2159-8290.CD-20-1109. Epub 2021 Jan 15.PMID: 33451982Free PMC article.
2. Chromatin regulators mediate anthracycline sensitivity in breast cancer. Seoane JA, Kirkland JG, Caswell-Jin JL, Crabtree GR, Curtis C.Nat Med. 2019 Nov;25(11):1721-1727. doi: 10.1038/s41591-019-0638-5. Epub 2019 Nov 7.PMID: 31700186

Professor of Medicine, Co-lead, Cancer Biology Program, Stanford Cancer Center

1. A CRISPR/Cas9-Engineered ARID1A-Deficient Human Gastric Cancer Organoid Model Reveals Essential and Nonessential Modes of Oncogenic Transformation. Lo YH, Kolahi KS, Du Y, Chang CY, Krokhotin A, Nair A, Sobba WD, Karlsson K, Jones SJ, Longacre TA, Mah AT, Tercan B, Sockell A, Xu H, Seoane JA, Chen J, Shmulevich I, Weissman JS, Curtis C, Califano A, Fu H, Crabtree GR, Kuo CJ. Cancer Discov. 2021 Jun;11(6):1562-1581. doi: 10.1158/2159-8290.CD-20-1109. Epub 2021 Jan 15.PMID: 33451982 Free PMC article.

2. Rapamycin selectively inhibits interleukin-2 activation of p70 S6 kinase.Kuo CJ, Chung J, Fiorentino DF, Flanagan WM, Blenis J, Crabtree GR. 1992 Jul 2;358(6381):70-3. doi: 10.1038/358070a0.PMID: 1614535
3. Rapamycin-FKBP specifically blocks growth-dependent activation of and signaling by the 70 kd S6 protein kinases. Chung J, Kuo CJ, Crabtree GR, Blenis J. Cell. 1992 Jun 26;69(7):1227-36. doi: 10.1016/0092-8674(92)90643-q.PMID: 1377606
4. A transcriptional hierarchy involved in mammalian cell-type specification. Kuo CJ, Conley PB, Chen L, Sladek FM, Darnell JE Jr, Crabtree GR. 1992 Jan 30;355(6359):457-61. doi: 10.1038/355457a0.PMID: 1734282
5. Independent regulation of HNF-1 alpha and HNF-1 beta by retinoic acid in F9 teratocarcinoma cells. Kuo CJ, Mendel DB, Hansen LP, Crabtree GR.EMBO J. 1991 Aug;10(8):2231-6. doi: 10.1002/j.1460-2075.1991.tb07759.x.PMID: 2065662Free PMC article.
6. Molecular cloning, functional expression, and chromosomal localization of mouse hepatocyte nuclear factor 1. Kuo CJ, Conley PB, Hsieh CL, Francke U, Crabtree GR. Proc Natl Acad Sci U S A. 1990 Dec;87(24):9838-42. doi: 10.1073/pnas.87.24.9838.PMID: 2263635Free PMC article.
7. HNF-1 shares three sequence motifs with the POU domain proteins and is identical to LF-B1 and APF. Baumhueter S, Mendel DB, Conley PB, Kuo CJ, Turk C, Graves MK, Edwards CA, Courtois G, Crabtree GR. Genes Dev. 1990 Mar;4(3):372-9. doi: 10.1101/gad.4.3.372.PMID: 1970973Free article.

D.H. Chen Professor of Bioengineering and of Psychiatry and Behavioral Sciences at Stanford University, and Investigator of the Howard Hughes Medical Institute.

Graef IA, Mermelstein PG, Stankunas K, Neilson JR, Deisseroth K, Tsien RW, Crabtree GR. L-type calcium channels and GSK-3 regulate the activity of NF-ATc4 in hippocampal neurons. Nature. 1999 Oct 14;401(6754):703-8. doi: 10.1038/44378. PMID: 10537109.

Professor of Dermatology in the School of Medicine. Chair Department of Dermatology, Stanford University School of Medicine

1. ACTL6a enforces the epidermal progenitor state by suppressing SWI/SNF-dependent induction of KLF4. Bao X, Tang J, Lopez-Pajares V, Tao S, Qu K, Crabtree GR, Khavari PA.Cell Stem Cell. 2013 Feb 7;12(2):193-203. doi: 10.1016/j.stem.2012.12.014.PMID: 23395444 Free PMC article.

2. Fas signal transduction triggers either proliferation or apoptosis in human fibroblasts. Freiberg RA, Spencer DM, Choate KA, Duh HJ, Schreiber SL, Crabtree GR, Khavari PA.J Invest Dermatol. 1997 Feb;108(2):215-9. doi: 10.1111/1523-1747.ep12334273.PMID: 9008237Free article.
3. Specific triggering of the Fas signal transduction pathway in normal human keratinocytes. Freiberg RA, Spencer DM, Choate KA, Peng PD, Schreiber SL, Crabtree GR, Khavari PA.J Biol Chem. 1996 Dec 6;271(49):31666-9. doi: 10.1074/jbc.271.49.31666.PMID: 8940187Free article.
4. Purification and biochemical heterogeneity of the mammalian SWI-SNF complex.Wang W, Côté J, Xue Y, Zhou S, Khavari PA, Biggar SR, Muchardt C, Kalpana GV, Goff SP, Yaniv M, Workman JL, Crabtree GR. EMBO J. 1996 Oct 1;15(19):5370-82.PMID: 8895581Free PMC article.
5. The retinoblastoma protein and BRG1 form a complex and cooperate to induce cell cycle arrest. Dunaief JL, Strober BE, Guha S, Khavari PA, Alin K, Luban J, Begemann M, Crabtree GR, Goff SP. 1994 Oct 7;79(1):119-30. doi: 10.1016/0092-8674(94)90405-7.PMID: 7923370
6. BRG1 contains a conserved domain of the SWI2/SNF2 family necessary for normal mitotic growth and transcription.Khavari PA, Peterson CL, Tamkun JW, Mendel DB, Crabtree GR. 1993 Nov 11;366(6451):170-4. doi: 10.1038/366170a0.PMID: 8232556
7. Characterization of a cofactor that regulates dimerization of a mammalian homeodomain protein.Mendel DB, Khavari PA, Conley PB, Graves MK, Hansen LP, Admon A, Crabtree GR. 1991 Dec 20;254(5039):1762-7. doi: 10.1126/science.1763325.PMID: 1763325

Robert C. Malenka is a Nancy Friend Pritzker Professor in Psychiatry and Behavioral Sciences at Stanford University. He is also the director of the Nancy Friend Pritzker Laboratory in the Stanford Medical Center.

1. Systemic enhancement of serotonin signaling reverses social deficits in multiple mouse models for ASD.Walsh JJ, Llorach P, Cardozo Pinto DF, Wenderski W, Christoffel DJ, Salgado JS, Heifets BD, Crabtree GR, Malenka RC. 2021 Oct;46(11):2000-2010. doi: 10.1038/s41386-021-01091-6. Epub 2021 Jul 8.PMID: 34239048

Loss of the neural-specific BAF subunit ACTL6B relieves repression of early response genes and causes recessive autism.Wenderski W, Wang L, Krokhotin A, Walsh JJ, Li H, Shoji H, Ghosh S, George RD, Miller EL, Elias L, Gillespie MA, Son EY, Staahl BT, Baek ST, Stanley V, Moncada C, Shipony Z, Linker SB, Marchetto MCN, Gage FH, Chen D, Sultan T, Zaki MS, Ranish JA, Miyakawa T, Luo L, Malenka RC, Crabtree GR, Gleeson JG.Proc Natl Acad Sci U S A. 2020 May 5;117(18):10055-10066. doi: 10.1073/pnas.1908238117. Epub 2020 Apr 20.PMID: 32312822

Neuroscientist, biotechnology executive, and academic leader. He served as Stanford University’s eleventh president.

Graef IA, Wang F, Charron F, Chen L, Neilson J, Tessier-Lavigne M, Crabtree GR. Neurotrophins and netrins require calcineurin/NFAT signaling to stimulate outgrowth of embryonic axons. Cell. 2003 May 30;113(5):657-70. doi: 10.1016/s0092-8674(03)00390-8. PMID: 12787506.